The Houston Technology Center is the sole building on the midtown block bounded by Pierce, Gray, Brazos and Bagby. It is easily reached via either I45 or Hwy 59. There are several parking lots, metered on-street parking and nearby parking garages. For a map of the parking options, please refer to the following webpage: http://www.houstontech.org/uploads/parkingmap.doc
From I45 S, take the Pierce/Bagby exit and stay to the right (it's best if you veer to the right where the streets diverge and stay on Bagby).
From I45 N, exit Scott/Downtown and then travel on St. Joseph Parkway, turn left onto Smith or you'll be routed downtown via Brazos or back onto I45 N.
From Hwy 59, exit Brazos and take it to Gray where you can turn left or to Pierce where you must turn right or enter downtown